Sperm DNA Fragmentation & Failed IVF Assessment in Abu Dhabi
An elevated sperm DNA fragmentation result needs interpretation alongside the semen analysis and both partners' fertility history. After unsuccessful IVF or ICSI, Dr. Juan Uría can review the male contribution in Abu Dhabi and coordinate next steps with your fertility team. A raised result alone does not explain every failed cycle.
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Dr. Juan Uría González-Tova · Consultant Urologist & Andrologist · NMC Royal Hospital Khalifa City, Abu Dhabi
Medically reviewed by Dr. Juan Uría · October 2, 2026
DNA fragmentation tests assess damage to sperm genetic material that a standard semen analysis does not directly measure. Tests use different methods and reference ranges, so percentages from different laboratories are not automatically comparable.
What the assessment involves
Bring the original laboratory reports and your IVF/ICSI treatment summaries.
Check the test method, collection conditions and whether repeating it would alter decisions.
Review semen results, relevant illnesses, medicines and testosterone or anabolic steroid exposure.
Examine for treatable findings such as a clinical varicocele; request other tests when indicated.
Consider the couple's timeline, partner's assessment and previous cycle outcomes together.
Treatment
Treat an identified cause rather than a laboratory number. A plan may address smoking, relevant illness or a clinically significant varicocele, while avoiding delays that disadvantage the couple's fertility treatment.
Antioxidants and testicular sperm retrieval are not automatic next steps. Their potential benefits, uncertainty, costs and risks require an individual discussion with the reproductive team.
Evidence
Read the clinical guidance and published evidence behind this page.
- EAU: male infertility — diagnostic work-up and sperm DNA fragmentation. Read source
- AUA/ASRM: diagnosis and treatment of infertility in men, part I. Read source
Common questions
01Is a DNA fragmentation result of 25% high?
It depends on the assay and laboratory reference range. Bring the full report; the percentage alone is insufficient for a treatment decision.
02Can a normal semen analysis exclude a male factor?
No. It is an important starting point, but selected couples need additional assessment. DNA fragmentation testing is not necessary for everyone.
03Should we assess the male partner after failed IVF or ICSI?
A male review is appropriate alongside assessment of the partner and cycle details. No test can assign blame or guarantee success in the next cycle.
04Does a high result mean I need TESE?
No. Surgery is considered only in selected circumstances after discussing alternatives and the limited evidence. It carries risks and does not guarantee a pregnancy.
About Dr. Juan Uría
Dr. Juan Uría González-Tova is a Consultant Urologist and Andrologist at NMC Royal Hospital, Khalifa City, Abu Dhabi, with over 30 years of clinical practice. He gained his medical degree at the University of Oviedo and his PhD at the University of Barcelona, and has practised in Abu Dhabi since 2018. Consultations are held in English, Spanish or Catalan.
View Dr. Uría's official NMC profileBook a consultation
Consultations take place at NMC Royal Hospital, Khalifa City, Abu Dhabi, in English, Spanish or Catalan.
Related topics
This page is general medical information and does not replace individual medical advice, diagnosis or treatment. If you have symptoms, seek assessment from a licensed physician.